Acretin 0.05% cream 30 gm
اكريتين 0.05% كريم 30 جرام
Tretinoin
Unit price: 43.00 EGP
Specifications
Uses & Indications
Tretinoin, a retinoid, is used topically to treat acne vulgaris and to reduce the appearance of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin (photoaging). Oral tretinoin is specifically indicated for the induction of remission in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, anthracycline chemotherapy, or for previously untreated APL patients.
How It Works
Tretinoin is a derivative of vitamin A (retinoic acid). Topically, it works by increasing cell turnover in the skin, promoting the shedding of old, damaged skin cells and stimulating the growth of new ones. This helps to unclog pores, reduce inflammation, and improve skin texture. Orally, in APL, tretinoin induces differentiation of immature promyelocytes into mature granulocytes, thereby reducing the proliferation of leukemic cells. It binds to specific retinoic acid receptors (RARs) in the cell nucleus, modulating gene expression.
Dosage & Administration
tablet
Adults: For Acute Promyelocytic Leukemia (APL), the recommended dose is 45 mg/m2/day, administered orally as two equally divided doses, until complete remission is achieved or for a maximum of 90 days.
Children: For Acute Promyelocytic Leukemia (APL), the recommended dose is 45 mg/m2/day, administered orally as two equally divided doses, until complete remission is achieved or for a maximum of 90 days.
topical
Adults: For acne vulgaris or photoaging, apply a thin layer to the affected areas once daily, typically at bedtime. Initial concentrations often start at 0.025% and may be increased to 0.05% or 0.1% as tolerated.
Children: For adolescents with acne, apply a thin layer to the affected areas once daily, typically at bedtime. Initial concentrations often start at 0.025%. Use in younger children should be under the guidance of a physician.
Side Effects
- Topical: Skin irritation (redness, peeling, dryness, burning, stinging) affecting up to 80% of users, increased sensitivity to sunlight (photosensitivity).
- Oral: Dry skin and mucous membranes (cheilitis, dry eyes, dry nose), headache (up to 70%), fever (up to 60%), bone pain, nausea, vomiting, rash.
Serious Side Effects
- Topical: Severe allergic reactions (rare), severe blistering or crusting of skin.
- Oral: Retinoic Acid Syndrome (RAS) characterized by fever, dyspnea, weight gain, pulmonary infiltrates, pleural or pericardial effusions, and hypotension, occurring in up to 25% of APL patients; pseudotumor cerebri (benign intracranial hypertension); severe hypertriglyceridemia; hepatotoxicity; severe teratogenicity.
Contraindications
Oral tretinoin is absolutely contraindicated in pregnancy due to severe teratogenicity. Both oral and topical forms are contraindicated in individuals with a known hypersensitivity to tretinoin or other retinoids. Oral tretinoin is also contraindicated in patients with severe uncontrolled hyperlipidemia or severe liver impairment.
Drug Interactions
Oral: Concomitant use with tetracyclines may increase the risk of pseudotumor cerebri. Avoid concurrent use of vitamin A supplements due to additive toxicity. Drugs that inhibit or induce CYP3A4 enzymes may alter tretinoin levels; consult your doctor or pharmacist. Topical: Concurrent use of other topical irritants, abrasive soaps, medicated cleansers, or products containing alcohol, astringents, or lime should be avoided as they may increase irritation. Use with caution alongside other photosensitizing agents.
Pregnancy & Lactation
Category: X
Tretinoin, especially in its oral form, is highly teratogenic and can cause severe birth defects. It is classified as Pregnancy Category X. Women of childbearing potential must have a negative pregnancy test within two weeks prior to starting oral tretinoin therapy and must use two reliable forms of contraception for one month before, during, and for one month after treatment. While topical absorption is minimal, topical tretinoin is generally avoided during pregnancy (often considered Category C by some sources for topical, but due to the known teratogenicity of retinoids, caution is paramount) and should only be used if the potential benefit justifies the potential risk, under strict medical supervision. Consult your doctor or pharmacist.
Storage
Store tretinoin tablets and topical preparations at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect from light and moisture. Keep out of reach of children.
Clinical Tips
When using topical tretinoin, apply a pea-sized amount to clean, dry skin at night. Sun protection (broad-spectrum sunscreen SPF 30+ and protective clothing) is crucial daily, as tretinoin increases sun sensitivity. An initial worsening of acne, known as "purging," can occur during the first few weeks of topical treatment; this is usually temporary. Consistency is key for optimal results, which may take 8-12 weeks to become apparent. Avoid waxing on treated skin. For oral tretinoin, strict adherence to contraception guidelines is paramount for women of childbearing potential.
Frequently Asked Questions
How long does it take for topical tretinoin to show results for acne?
It typically takes 8 to 12 weeks of consistent topical tretinoin use to see noticeable improvements in acne. An initial worsening of acne, known as "purging," can occur during the first few weeks of treatment.
Can I use tretinoin if I am pregnant or planning to become pregnant?
Oral tretinoin is strictly contraindicated during pregnancy due to severe risks of birth defects. Topical tretinoin is also generally avoided during pregnancy. If you are pregnant or planning to conceive, consult your doctor immediately.
Do I need to use sunscreen while using topical tretinoin?
Yes, daily use of a broad-spectrum sunscreen with an SPF of 30 or higher is crucial when using topical tretinoin. Tretinoin increases your skin's sensitivity to the sun, making it more prone to sunburn.
What is "purging" when using topical tretinoin?
"Purging" refers to an initial worsening of acne that some individuals experience when starting topical tretinoin. This occurs as the medication speeds up cell turnover, bringing underlying clogged pores to the surface, and typically resolves within a few weeks.
Can I use other acne treatments with topical tretinoin?
It is generally advisable to avoid using other strong topical irritants or acne treatments (like benzoyl peroxide or salicylic acid) simultaneously with tretinoin, as this can increase skin irritation. Consult your doctor or pharmacist before combining treatments.
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Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.