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Anti-Infective - Penicillin Antibiotics (Monocomponent)

Amoxicillin 500mg 12 caps.

اموكسيسيللين 500 مجم 12 كبسولة

Amoxicillin

8.00 EGP9.50 EGP-16%

Unit price: 4.00 EGP

Specifications

Manufacturer
October pharma
Units / Box
2
Barcode
6221088021464
Price Updated
Jun 24, 2023

Uses & Indications

Amoxicillin is a penicillin-class antibiotic used to treat a wide range of bacterial infections. These include respiratory tract infections (e.g., sinusitis, bronchitis, pneumonia), ear infections (otitis media), throat infections (streptococcal pharyngitis), urinary tract infections, skin and soft tissue infections, and Helicobacter pylori eradication (in combination therapy).

How It Works

Amoxicillin is a beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are essential for the synthesis of peptidoglycan, a major component of the bacterial cell wall. This inhibition leads to defective cell walls, increased osmotic pressure, and ultimately bacterial cell lysis and death.

Dosage & Administration

drops

Adults: Not typically available or used in drops form for adults. Consult physician.

Children: Dosage varies by weight and infection severity. For infants <3 months, typically 20-30 mg/kg/day divided every 12 hours. For infants >3 months, 20-45 mg/kg/day divided every 8-12 hours. Maximum 500 mg per dose. Consult physician.

syrup

Adults: Not typically used for adults; tablets are preferred. Consult physician.

Children: Dosage varies by weight and infection. Common doses range from 20-45 mg/kg/day divided every 8-12 hours. For example, 125 mg or 250 mg three times daily for mild-moderate infections. Maximum 500 mg per dose. Consult physician.

tablet

Adults: Standard doses range from 250 mg to 500 mg every 8 hours, or 500 mg to 875 mg every 12 hours, depending on the infection. For severe infections, up to 875 mg three times daily.

Children: Dosage varies by weight and infection. Typically 20-45 mg/kg/day divided every 8-12 hours. For example, 250 mg three times daily for children weighing >40 kg. Consult physician.

injectable

Adults: Typically 500 mg to 1 g every 6-8 hours, depending on the infection. Maximum 12 g/day. Administered intravenously or intramuscularly.

Children: 20-50 mg/kg/day divided every 8 hours, up to 100 mg/kg/day for severe infections. Maximum 2 g/day. Administered intravenously or intramuscularly. Consult physician.

Side Effects

  • Nausea (1-10%)
  • Vomiting (1-10%)
  • Diarrhea (1-10%)
  • Rash (1-10%)
  • Headache (less than 1%)

Serious Side Effects

  • Severe allergic reactions (anaphylaxis, angioedema) (rare, <0.1%)
  • Clostridioides difficile-associated diarrhea (CDAD)
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Liver dysfunction
  • Kidney problems
  • Blood dyscrasias (e.g., thrombocytopenia, leukopenia)

Contraindications

Known hypersensitivity to amoxicillin, other penicillins, or any component of the formulation. History of severe allergic reaction to any beta-lactam antibiotic (e.g., cephalosporins, carbapenems).

Drug Interactions

Warfarin: May increase the anticoagulant effect of warfarin, requiring closer INR monitoring. Methotrexate: May decrease renal clearance of methotrexate, increasing its toxicity. Allopurinol: Concomitant use may increase the incidence of skin rash. Oral Contraceptives: May reduce the efficacy of oral contraceptives (though evidence is limited, an alternative birth control method is often advised). Probenecid: Decreases renal tubular secretion of amoxicillin, leading to increased and prolonged blood levels of amoxicillin.

Pregnancy & Lactation

Category: B

Amoxicillin is generally considered safe for use during pregnancy. Studies in animals have not shown harm to the fetus, and controlled studies in pregnant women have not demonstrated a risk. However, it should only be used if clearly needed and under medical supervision.

Storage

Store at room temperature (20-25°C), away from moisture and direct light. Reconstituted oral suspensions should be stored in a refrigerator (2-8°C) and discarded after 14 days (or as per product specific instructions). Do not freeze.

Clinical Tips

Complete the full course of antibiotics as prescribed, even if symptoms improve, to prevent antibiotic resistance. Amoxicillin can be taken with or without food. If a dose is missed, take it as soon as remembered unless it is almost time for the next dose; do not double dose. Consult your doctor or pharmacist for personalized advice.

Frequently Asked Questions

Can I stop taking amoxicillin once I feel better?

No, it is crucial to complete the entire course of amoxicillin as prescribed by your doctor, even if your symptoms improve. Stopping early can lead to the infection returning and contribute to antibiotic resistance.

What should I do if I miss a dose of amoxicillin?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Can amoxicillin cause an allergic reaction?

Yes, amoxicillin can cause allergic reactions, ranging from mild skin rashes to severe anaphylaxis. If you experience hives, difficulty breathing, or swelling of the face or throat, seek immediate medical attention. Inform your doctor if you have any history of penicillin allergy.

Does amoxicillin interact with birth control pills?

While the evidence is limited, some antibiotics, including amoxicillin, may potentially reduce the effectiveness of oral contraceptives. It is advisable to discuss this with your doctor or pharmacist and consider using an alternative or additional birth control method during treatment.

Can I drink alcohol while taking amoxicillin?

Generally, there is no direct interaction between amoxicillin and alcohol that would cause harmful effects. However, alcohol can worsen some side effects like nausea or dizziness, and it may also impair your body's ability to fight infection. It is often best to limit or avoid alcohol while unwell and on medication.

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Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.