Andovit neuro 20 f.c. tabs.
اندوفيت نيورو 20 قرص
Benfotiamine+cyanocobalamine+pyridoxine
Unit price: 65.00 EGP
Specifications
Uses & Indications
This medication, a combination of benfotiamine (a lipid-soluble derivative of vitamin B1), cyanocobalamin (vitamin B12), and pyridoxine (vitamin B6), is primarily used to treat and prevent deficiencies of these B vitamins. It is commonly prescribed for conditions associated with nerve damage, such as diabetic neuropathy, alcoholic neuropathy, and other forms of peripheral neuropathy, to help alleviate symptoms like pain, tingling, and numbness. It may also be used in cases of general vitamin B deficiency.
How It Works
Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that is more readily absorbed and has higher bioavailability than water-soluble thiamine. It helps to prevent the accumulation of advanced glycation end-products (AGEs) and supports nerve cell metabolism. Cyanocobalamin (vitamin B12) is crucial for the synthesis of myelin, the protective sheath around nerves, and plays a vital role in red blood cell formation and DNA synthesis. Pyridoxine (vitamin B6) is involved in numerous metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and the formation of myelin. Together, these B vitamins support healthy nerve function, aid in nerve regeneration, and help reduce oxidative stress and inflammation, thereby improving neuropathic symptoms.
Dosage & Administration
tablet
Adults: The typical adult dosage is 1 tablet once daily, preferably with a meal, or as directed by a healthcare professional. Dosage may vary based on the severity of the deficiency or condition being treated.
Children: This combination is generally not recommended for routine use in children. Pediatric dosing should only be determined by a physician based on individual needs and specific medical conditions.
Side Effects
- Nausea (approximately 1-10%)
- Stomach upset or abdominal pain (approximately 1-10%)
- Diarrhea (approximately 1-10%)
- Headache (approximately 1-10%)
- Unpleasant taste in mouth (less common)
Serious Side Effects
- Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing) - rare
- Peripheral neuropathy (with very high, prolonged doses of pyridoxine, typically >200 mg/day)
- Megaloblastic anemia masking (if vitamin B12 is given to a patient with folate deficiency without addressing the folate deficiency)
Contraindications
This medication is contraindicated in individuals with known hypersensitivity to benfotiamine, cyanocobalamin, pyridoxine, or any other component of the formulation. It should also be avoided in patients with Leber's disease or other optic neuropathies, as cyanocobalamin may exacerbate these conditions.
Drug Interactions
Pyridoxine (vitamin B6) can reduce the effectiveness of levodopa (used for Parkinson's disease) unless a peripheral decarboxylase inhibitor is also administered. It may also interact with phenobarbital and phenytoin, potentially reducing their serum concentrations. Metformin, proton pump inhibitors (PPIs), and H2-receptor antagonists can decrease the absorption of cyanocobalamin (vitamin B12). Chloramphenicol may reduce the hematologic response to vitamin B12. Consult your doctor or pharmacist about all medications and supplements you are taking.
Pregnancy & Lactation
Category: A
Benfotiamine, cyanocobalamin, and pyridoxine are essential vitamins. At recommended dietary allowances, they are generally considered safe during pregnancy (Category A). However, high doses of pyridoxine (vitamin B6) have been associated with adverse effects. This combination should only be used during pregnancy if clearly needed and under the guidance of a healthcare professional, who can weigh the potential benefits against any risks.
Storage
Store the tablets at room temperature, typically between 20°C to 25°C (68°F to 77°F), away from moisture and direct light. Keep the medication in its original packaging and out of the reach of children.
Clinical Tips
Take this medication consistently as prescribed by your doctor. It is often recommended to take it with food to minimize stomach upset. Do not exceed the recommended dose without consulting your healthcare provider, especially for prolonged periods, as excessive intake of certain B vitamins, particularly B6, can lead to adverse effects. If you experience any unusual or severe side effects, seek medical attention promptly.
Frequently Asked Questions
What is benfotiamine+cyanocobalamin+pyridoxine used for?
This medication is primarily used to treat and prevent deficiencies of vitamins B1, B12, and B6. It is commonly prescribed for nerve-related conditions like diabetic neuropathy to help reduce symptoms such as pain, tingling, and numbness.
How should I take this medication?
Typically, adults take one tablet once daily, preferably with a meal, or as directed by their doctor. It is important to follow your healthcare provider's instructions regarding dosage and duration of treatment.
What are the common side effects of this medication?
Common side effects may include nausea, stomach upset, diarrhea, and headache. These are usually mild and temporary. If any side effect persists or worsens, consult your doctor or pharmacist.
Can I take this medication if I am pregnant?
While these are essential vitamins, high doses of certain B vitamins, particularly B6, can be problematic during pregnancy. It is crucial to consult your doctor before taking this medication if you are pregnant or planning to become pregnant, to ensure it is safe and appropriate for your specific situation.
How long does it take for this medication to start working?
The time it takes to notice improvement can vary depending on the individual and the severity of the deficiency or condition being treated. Some individuals may experience relief from symptoms within a few weeks, while others may require longer treatment to observe significant benefits. Consistent use as prescribed is important.
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Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.