Drugex
العربيةOpen App
Anti-Infective - Cephalosporin Antibiotics (Second Generation)

Cefaclor 500mg 12caps.usp 23 (n/a)

سيفاكلور 500 مجم 12 كبسول

Cefaclor

32.00 EGP

Unit price: 16.00 EGP

Specifications

Manufacturer
Pharco b
Units / Box
2
Barcode
6222012222001
Price Updated
Dec 3, 2022

Uses & Indications

Cefaclor is an antibiotic used to treat various bacterial infections. These include infections of the respiratory tract (such as bronchitis, pneumonia, pharyngitis, and tonsillitis), otitis media (middle ear infection), skin and soft tissue infections, and urinary tract infections (UTIs). It is effective against certain bacteria that are susceptible to its action.

How It Works

Cefaclor is a second-generation cephalosporin antibiotic. It works by interfering with the synthesis of the bacterial cell wall, which is essential for the survival and integrity of bacteria. By inhibiting the cross-linking of peptidoglycan strands, cefaclor causes the bacterial cell wall to weaken and rupture, leading to bacterial cell death. This makes it a bactericidal agent.

Dosage & Administration

syrup

Adults: Not typically used for adults; tablet form is preferred. If used, consult physician for appropriate dosing.

Children: For most infections, 20 mg/kg/day in divided doses every 8 hours. For more severe infections like otitis media, 40 mg/kg/day in divided doses every 8 hours, up to a maximum of 1 gram per day.

tablet

Adults: For most infections, 250 mg every 8 hours. For more severe infections or those caused by less susceptible organisms, 500 mg every 8 hours. The maximum recommended daily dose is 4 grams.

Children: Not typically recommended for children who cannot swallow tablets; syrup form is preferred. If used, consult physician for appropriate dosing.

Side Effects

  • Diarrhea (occurs in approximately 2-10% of patients)
  • Nausea (occurs in approximately 1-5% of patients)
  • Vomiting (occurs in approximately 1-5% of patients)
  • Rash (occurs in approximately 1-5% of patients)
  • Eosinophilia (increased white blood cells, approximately 1-5%)
  • Genital pruritus (itching)

Serious Side Effects

  • Severe allergic reactions (anaphylaxis, angioedema, Stevens-Johnson syndrome)
  • Clostridioides difficile-associated diarrhea (CDAD), which can range from mild diarrhea to fatal colitis
  • Hemolytic anemia
  • Thrombocytopenia (low platelet count)
  • Agranulocytosis (severe low white blood cell count)
  • Renal dysfunction or interstitial nephritis
  • Seizures (rare)

Contraindications

Cefaclor is contraindicated in patients with a known hypersensitivity to cefaclor or to any other cephalosporin antibiotics. It should be used with caution in patients with a history of severe allergic reactions to penicillin, as cross-reactivity can occur.

Drug Interactions

Concurrent administration of cefaclor with oral anticoagulants like warfarin may prolong prothrombin time, requiring careful monitoring of INR. Probenecid can increase and prolong cefaclor serum concentrations by inhibiting its renal excretion. Antacids containing magnesium or aluminum hydroxide may decrease the absorption of cefaclor, reducing its effectiveness. Avoid taking cefaclor within 1 hour before or 2 hours after antacids.

Pregnancy & Lactation

Category: B

Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Cefaclor should be used during pregnancy only if clearly needed and after consulting with a healthcare professional to weigh the potential benefits against any potential risks.

Storage

Store cefaclor tablets and reconstituted syrup at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep the medication tightly closed and protected from moisture. Reconstituted oral suspension should be stored in a refrigerator (2°C to 8°C or 36°F to 46°F) and discarded after 14 days.

Clinical Tips

It is important to complete the full course of cefaclor as prescribed by your doctor, even if your symptoms improve, to prevent the infection from returning and to reduce the development of antibiotic resistance. Cefaclor may be taken with food if stomach upset occurs. This medication is an antibiotic and is not effective against viral infections like the common cold or flu.

Frequently Asked Questions

What is Cefaclor used for?

Cefaclor is an antibiotic used to treat various bacterial infections, including respiratory tract infections, ear infections (otitis media), skin infections, and urinary tract infections. It works by killing susceptible bacteria.

How should I take Cefaclor?

Take Cefaclor exactly as prescribed by your doctor. It can be taken with or without food, but taking it with food may help reduce stomach upset. Complete the full course of treatment, even if you start feeling better.

What are the common side effects of Cefaclor?

Common side effects include diarrhea, nausea, vomiting, and skin rash. If these side effects become severe or persistent, consult your doctor or pharmacist. Serious allergic reactions are rare but require immediate medical attention.

Can Cefaclor be taken during pregnancy?

Cefaclor is classified as Pregnancy Category B. While animal studies have shown no harm, there are limited studies in pregnant women. It should only be used during pregnancy if clearly needed and after consulting a healthcare professional.

What should I do if I miss a dose of Cefaclor?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Similar — Cefaclor

Compare prices with Drugex

Price calculator, stock management, AI analysis

Open in Drugex

Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.