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Gastrointestinal - Proton Pump Inhibitors (PPIs)

Controloc 40mg 14 gastroresistant tab

كونترولوك 40مجم 14 قرص

Pantoprazole

188.00 EGP

Unit price: 188.00 EGP

Specifications

Manufacturer
pharma over seas
Units / Box
1
Price Updated
Feb 19, 2025

Uses & Indications

Pantoprazole is a proton pump inhibitor (PPI) used to treat conditions caused by excessive stomach acid. These conditions include gastroesophageal reflux disease (GERD), erosive esophagitis (damage to the esophagus from stomach acid), Zollinger-Ellison syndrome (a condition causing overproduction of stomach acid), and as part of a multi-drug regimen to eradicate Helicobacter pylori infection.

How It Works

Pantoprazole works by irreversibly blocking the H+/K+ ATPase enzyme system, also known as the proton pump, located on the secretory surface of the gastric parietal cells. This blockade prevents the final step of acid production, leading to a significant and sustained reduction in gastric acid secretion. This action helps to heal acid-related damage and relieve symptoms.

Dosage & Administration

tablet

Adults: For erosive esophagitis: 40 mg once daily for up to 8 weeks. Maintenance of healing of erosive esophagitis: 40 mg once daily. For GERD: 40 mg once daily. For Zollinger-Ellison syndrome: Initial dose of 40 mg twice daily, adjusted as needed. For H. pylori eradication: 40 mg twice daily in combination with antibiotics, typically for 7-14 days.

Children: For erosive esophagitis in children 5 years and older: weighing 15-40 kg, 20 mg once daily; weighing >40 kg, 40 mg once daily. Duration up to 8 weeks. For other indications, consult a physician.

injectable

Adults: For erosive esophagitis: 40 mg once daily via intravenous infusion over 2 to 15 minutes. For Zollinger-Ellison syndrome: Initial dose of 80 mg IV every 12 hours, adjusted as needed based on acid output. Doses up to 240 mg/day have been administered.

Children: Not routinely recommended for children via injectable form. Specific indications and dosing for pediatric patients must be determined by a specialist, considering the child's weight and condition.

Side Effects

  • Headache (approximately 1-5%)
  • Nausea (approximately 1-4%)
  • Diarrhea (approximately 1-4%)
  • Abdominal pain (approximately 1-4%)
  • Flatulence (approximately 1-2%)
  • Dizziness (approximately 1-2%)

Serious Side Effects

  • Clostridium difficile-associated diarrhea (CDAD)
  • Acute interstitial nephritis (inflammation of the kidneys)
  • Bone fractures (with long-term, high-dose use, particularly of the hip, wrist, or spine)
  • Hypomagnesemia (low magnesium levels, especially with prolonged use >3 months)
  • Vitamin B12 deficiency (with prolonged use >3 years)
  • Cutaneous and systemic lupus erythematosus (rarely reported)
  • Severe skin reactions (e.g., Stevens-Johnson syndrome)

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to pantoprazole, substituted benzimidazoles (other PPIs), or any component of the formulation. It should not be used with rilpivirine-containing products.

Drug Interactions

Pantoprazole can interact with several medications. It may reduce the absorption of drugs that depend on gastric pH for absorption, such as atazanavir, nelfinavir, iron salts, ketoconazole, and itraconazole. Concomitant use with clopidogrel may reduce its antiplatelet effect. It may increase systemic exposure to methotrexate, especially with high doses. Warfarin's INR may be increased in some patients, requiring monitoring. Inform your doctor or pharmacist about all medications, including over-the-counter drugs and herbal supplements, before starting pantoprazole.

Pregnancy & Lactation

Category: B

Animal reproduction studies have not demonstrated a risk to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Pantoprazole should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks.

Storage

Pantoprazole tablets should be stored at room temperature, between 20°C and 25°C (68°F and 77°F), protected from moisture and light. The reconstituted injectable solution should be used within 24 hours when stored at room temperature or refrigerated at 2°C to 8°C (36°F to 46°F).

Clinical Tips

Pantoprazole tablets should be swallowed whole and not crushed, chewed, or split. For best results, take the tablet 30-60 minutes before a meal, typically in the morning. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose. Long-term use of PPIs may require monitoring for bone density and magnesium levels. Consult your doctor or pharmacist if you experience persistent or worsening symptoms.

Frequently Asked Questions

What is pantoprazole used for?

Pantoprazole is used to treat conditions caused by too much stomach acid, such as gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome. It helps heal acid damage to the esophagus and prevents ulcers.

How should I take pantoprazole tablets?

Pantoprazole tablets should be taken whole, 30 to 60 minutes before a meal, usually in the morning. Do not crush, chew, or break the tablet, as this can affect its effectiveness.

What are the common side effects of pantoprazole?

Common side effects include headache, nausea, diarrhea, abdominal pain, and flatulence. These are usually mild and temporary. If they persist or worsen, consult your doctor or pharmacist.

Can I take pantoprazole long-term?

Long-term use of pantoprazole, especially for more than a year, may be associated with an increased risk of certain side effects like bone fractures, hypomagnesemia, and vitamin B12 deficiency. Your doctor will assess the need for long-term therapy and monitor you accordingly.

Does pantoprazole interact with other medications?

Yes, pantoprazole can interact with several medications, including blood thinners like warfarin, antiplatelet drugs like clopidogrel, and certain antiviral medications. Always inform your doctor or pharmacist about all medications and supplements you are taking to avoid potential interactions.

Similar — Pantoprazole

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Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.