Dimra 20 f.c.tab.
ديمرا 50مجم 20 قرص
Diclofenac potassium+methocarbamol
Unit price: 35.00 EGP
Specifications
Uses & Indications
Diclofenac potassium + methocarbamol is a combination medication used to relieve pain and muscle spasms associated with acute, painful musculoskeletal conditions. It is indicated for conditions such as back pain, neck pain, sprains, strains, and other injuries where both pain and muscle stiffness are present.
How It Works
This medication combines two active ingredients: diclofenac potassium and methocarbamol. Diclofenac potassium is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By reducing prostaglandin production, diclofenac helps to decrease pain and inflammation. Methocarbamol is a centrally acting muscle relaxant. Its exact mechanism of action is not fully understood, but it is believed to act on the central nervous system (brain and spinal cord) to produce its muscle relaxant effects, rather than directly on the skeletal muscles. It also has general CNS depressant properties.
Dosage & Administration
tablet
Adults: The usual adult dose is 1 tablet (e.g., containing 50 mg diclofenac potassium and 500 mg methocarbamol) taken 2 to 3 times daily. The maximum daily dose of diclofenac should generally not exceed 150 mg. Treatment should be for the shortest duration necessary to achieve symptom relief. Always consult your doctor or pharmacist for precise dosing instructions.
Children: This medication is generally not recommended for children under 12 years of age. For pediatric use, consult a physician.
Side Effects
- Drowsiness (up to 25% of patients)
- Dizziness (up to 15% of patients)
- Nausea
- Dyspepsia (indigestion)
- Abdominal pain
- Headache
- Lightheadedness
- Blurred vision
Serious Side Effects
- Gastrointestinal bleeding or ulceration (e.g., black, tarry stools; vomiting blood)
- Cardiovascular thrombotic events (e.g., heart attack, stroke)
- Kidney impairment or failure
- Liver dysfunction (e.g., jaundice, dark urine)
- Severe allergic reactions (e.g., rash, itching, swelling of face/throat, severe dizziness, trouble breathing)
- Severe skin reactions (e.g., Stevens-Johnson syndrome)
- Blood dyscrasias (e.g., anemia)
Contraindications
This medication is contraindicated in individuals with known hypersensitivity to diclofenac, methocarbamol, aspirin, or other NSAIDs. It should not be used in patients with active gastrointestinal bleeding, peptic ulcer disease, severe heart failure, severe renal impairment, or severe hepatic impairment. It is also contraindicated for peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery and during the third trimester of pregnancy.
Drug Interactions
Concurrent use with other NSAIDs or aspirin increases the risk of gastrointestinal side effects and bleeding. Anticoagulants (e.g., warfarin) and antiplatelet agents (e.g., clopidogrel) can increase the risk of bleeding. Diuretics, ACE inhibitors, and ARBs may have their effects reduced and increase the risk of renal impairment. Lithium, methotrexate, cyclosporine, and digoxin levels may be increased. Methocarbamol can enhance the sedative effects of alcohol, other CNS depressants (e.g., benzodiazepines, opioids), and some antihistamines. Consult your doctor or pharmacist about all medications you are taking.
Pregnancy & Lactation
Category: C (first and second trimesters), D (third trimester)
Diclofenac potassium + methocarbamol should be used during the first and second trimesters of pregnancy only if the potential benefit justifies the potential risk to the fetus. It is contraindicated in the third trimester due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction in the fetus. Methocarbamol's safety in pregnancy has not been definitively established. Always consult your doctor before using this medication during pregnancy.
Storage
Store at room temperature, typically between 15°C and 30°C (59°F and 86°F). Protect from moisture and light. Keep the medication in its original packaging and out of the reach of children.
Clinical Tips
This medication may cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them. It is advisable to take this medication with food or milk to minimize gastrointestinal upset. Do not exceed the prescribed dose or duration of treatment, as this can increase the risk of side effects. Avoid consuming alcohol while taking this medication due to increased sedative effects. Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) or severe allergic reactions immediately to a healthcare professional.
Frequently Asked Questions
What is diclofenac potassium + methocarbamol used for?
This medication is used to relieve pain and muscle spasms associated with acute musculoskeletal conditions like back pain, sprains, and strains. It combines an anti-inflammatory pain reliever (diclofenac) with a muscle relaxant (methocarbamol).
Can I drive while taking this medication?
No, this medication can cause drowsiness and dizziness. It is important to avoid driving or operating heavy machinery until you know how the medication affects you and are certain it does not impair your ability to perform such tasks safely.
How quickly does this medication start to work?
Due to the diclofenac potassium component, which is rapidly absorbed, pain relief can often begin within 30 minutes to 1 hour. The muscle relaxant effect of methocarbamol typically also starts within a similar timeframe.
What are the serious side effects I should watch out for?
Serious side effects include gastrointestinal bleeding (black, tarry stools; vomiting blood), severe allergic reactions (rash, swelling, trouble breathing), kidney or liver problems, and cardiovascular events. Seek immediate medical attention if you experience any of these.
Can I take this medication with other pain relievers?
You should generally avoid taking this medication with other NSAIDs (like ibuprofen or naproxen) or aspirin, as this increases the risk of serious side effects, especially gastrointestinal bleeding. Always consult your doctor or pharmacist before combining pain relievers.
Similar — Diclofenac potassium+methocarbamol
Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.