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General Health - Vitamin D Supplements

Diviton-d forte 10.000 i.u./ml oral drops 20 ml

ديفيتون-دي فورت 10000 وحدة دولية/مل نقط بالفم 20 مل

Cholecalciferol(vitamin d3)

93.00 EGP

Unit price: 93.00 EGP

Specifications

Manufacturer
Al esraa pharmaceutical optima
Units / Box
1
Barcode
6223004161193
Price Updated
Aug 29, 2023

Uses & Indications

Cholecalciferol, also known as Vitamin D3, is primarily used for the treatment and prevention of vitamin D deficiency. It is essential for calcium and phosphate homeostasis, playing a crucial role in bone health. Indications include rickets, osteomalacia, osteoporosis (as an adjunct to other therapies), and hypoparathyroidism. It is also used in individuals with malabsorption syndromes or those at high risk of deficiency.

How It Works

Cholecalciferol (Vitamin D3) is an inactive precursor that requires two hydroxylation steps to become its active form, 1,25-dihydroxycholecalciferol (calcitriol). The first hydroxylation occurs in the liver, converting cholecalciferol to 25-hydroxycholecalciferol (calcifediol). The second hydroxylation takes place primarily in the kidneys, converting calcifediol to calcitriol. Calcitriol then acts on target tissues, primarily the intestines, kidneys, and bone, to regulate calcium and phosphate levels. It promotes calcium and phosphate absorption from the gut, enhances renal reabsorption of calcium and phosphate, and facilitates bone mineralization and remodeling.

Dosage & Administration

drops

Adults: For vitamin D deficiency, typical doses range from 1000 IU to 4000 IU (e.g., 2-4 drops of a 1000 IU/drop solution) daily, or as directed by a physician based on serum 25(OH)D levels. Higher doses may be used for initial repletion.

Children: For prevention of rickets in infants, 400 IU (e.g., 1 drop of a 400 IU/drop solution) daily. For treatment of deficiency, doses typically range from 400 IU to 1000 IU daily, depending on age, weight, and severity, under medical supervision. Consult a physician for specific dosing.

tablet

Adults: For vitamin D deficiency, typical doses range from 1000 IU to 5000 IU daily, or 50,000 IU once weekly to once monthly, based on serum 25(OH)D levels and physician's guidance. For osteoporosis prevention/treatment, 800 IU to 1000 IU daily in conjunction with calcium.

Children: For vitamin D deficiency, doses typically range from 400 IU to 1000 IU daily, depending on age, weight, and severity, under medical supervision. Consult a physician for specific dosing.

injectable

Adults: For severe vitamin D deficiency, an intramuscular injection of 100,000 IU to 300,000 IU may be administered every 1 to 3 months, or as prescribed by a physician, particularly in cases of malabsorption or poor adherence to oral therapy.

Children: Injectable cholecalciferol is not commonly used for routine pediatric deficiency. In severe cases, specific dosing should be determined by a physician based on the child's condition and weight.

Side Effects

  • Nausea (less than 1%)
  • Vomiting (less than 1%)
  • Constipation (less than 1%)
  • Abdominal pain (less than 1%)
  • Loss of appetite (less than 1%)
  • Dry mouth (less than 1%)
  • Fatigue (less than 1%)

Serious Side Effects

  • Severe hypercalcemia (rare, typically with excessive doses)
  • Nephrolithiasis (kidney stones, rare)
  • Nephrocalcinosis (calcium deposits in kidneys, rare)
  • Cardiac arrhythmias (rare, due to severe hypercalcemia)
  • Pancreatitis (rare)

Contraindications

Cholecalciferol is contraindicated in individuals with hypercalcemia, vitamin D toxicity, or known hypersensitivity to cholecalciferol or any component of the formulation. It should be used with caution in patients with severe renal impairment, sarcoidosis, or other granulomatous diseases due to increased sensitivity to vitamin D effects.

Drug Interactions

Certain medications can interact with cholecalciferol. Thiazide diuretics may increase the risk of hypercalcemia. Digoxin toxicity can be exacerbated by hypercalcemia. Anticonvulsants (e.g., phenytoin, phenobarbital) and corticosteroids may increase vitamin D metabolism, potentially requiring higher cholecalciferol doses. Orlistat, cholestyramine, and mineral oil can impair the absorption of fat-soluble vitamins, including cholecalciferol. Consult your doctor or pharmacist about all medications and supplements you are taking.

Pregnancy & Lactation

Category: C

Vitamin D is essential during pregnancy for both maternal and fetal health. Doses up to 4000 IU/day are generally considered safe when medically indicated to treat or prevent deficiency. However, excessive doses should be avoided due to potential risks of hypercalcemia in the mother and fetus. Consult your physician to determine the appropriate dosage during pregnancy and lactation.

Storage

Store cholecalciferol preparations at room temperature, typically between 15°C and 30°C (59°F and 86°F), away from direct light and moisture. Keep the medication in its original packaging and out of reach of children.

Clinical Tips

Cholecalciferol is a fat-soluble vitamin, and its absorption can be enhanced when taken with food, especially meals containing some fat. Regular monitoring of serum calcium and 25(OH)D levels is important, particularly during high-dose therapy, to ensure efficacy and prevent toxicity. Do not exceed the prescribed dosage without consulting a healthcare professional.

Frequently Asked Questions

What is cholecalciferol used for?

Cholecalciferol, also known as Vitamin D3, is primarily used to treat and prevent vitamin D deficiency. It is crucial for bone health, helping the body absorb calcium and phosphorus, and is also used in conditions like osteoporosis, rickets, and osteomalacia.

How should I take cholecalciferol for best absorption?

Cholecalciferol is a fat-soluble vitamin, so it is best absorbed when taken with a meal that contains some fat. This can significantly improve its bioavailability.

Can I take cholecalciferol if I am pregnant?

Vitamin D is essential during pregnancy for both maternal and fetal health. However, it is crucial to consult your doctor to determine the appropriate dosage, as excessive intake can be harmful. Doses up to 4000 IU/day are generally considered safe when medically indicated.

What happens if I take too much cholecalciferol?

Taking excessive amounts of cholecalciferol can lead to vitamin D toxicity, characterized by hypercalcemia (high calcium levels in the blood). Symptoms may include nausea, vomiting, constipation, fatigue, and in severe cases, kidney damage or heart rhythm problems. Always adhere to the prescribed dose.

How long does it take for cholecalciferol to work?

The time it takes for cholecalciferol to raise vitamin D levels can vary depending on the severity of the deficiency and the dosage. Significant improvements in blood levels are typically observed within weeks to a few months of consistent supplementation. Regular blood tests are used to monitor progress.

Similar — Cholecalciferol(vitamin d3)

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Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.