E-moxclav 1gm 10 f.c. tab
ايموكسكلاف 1جم 10 اقراص
Amoxicillin+clavulanic acid
Unit price: 96.00 EGP
Specifications
Uses & Indications
Amoxicillin/clavulanic acid is a combination antibiotic used to treat a wide range of bacterial infections. These include infections of the upper and lower respiratory tract (e.g., sinusitis, otitis media, bronchitis, pneumonia), urinary tract, skin and soft tissue, and bone and joint infections. It is effective against bacteria that produce beta-lactamase enzymes, which would otherwise inactivate amoxicillin alone.
How It Works
This medication combines amoxicillin, a penicillin-class beta-lactam antibiotic, with clavulanic acid, a beta-lactamase inhibitor. Amoxicillin works by interfering with the synthesis of the bacterial cell wall, leading to cell lysis and death. Clavulanic acid, by inhibiting bacterial beta-lactamase enzymes, protects amoxicillin from degradation, thereby extending its spectrum of activity against many amoxicillin-resistant bacteria.
Dosage & Administration
drops
Adults: Not typically used in adults; consult physician for appropriate formulation.
Children: For infants and young children, dosage is based on amoxicillin component. Common dosing is 25-45 mg/kg/day of amoxicillin, divided every 12 hours. For example, a common concentration is 125 mg amoxicillin/31.25 mg clavulanic acid per 1.25 mL. Dosing must be precise and based on child's weight and infection severity, as directed by a physician.
syrup
Adults: Not typically used in adults; consult physician for appropriate formulation.
Children: Dosage is based on amoxicillin component, typically 20-45 mg/kg/day, divided every 8 or 12 hours depending on the specific formulation (e.g., 250 mg/62.5 mg per 5 mL or 400 mg/57 mg per 5 mL) and severity of infection. Maximum daily dose for children should not exceed 45 mg/kg/day of amoxicillin.
tablet
Adults: For mild to moderate infections, 500 mg amoxicillin/125 mg clavulanic acid every 8 hours, or 875 mg amoxicillin/125 mg clavulanic acid every 12 hours. For more severe infections, 875 mg amoxicillin/125 mg clavulanic acid every 12 hours. Dosage should be adjusted for renal impairment.
Children: Not typically recommended for children due to fixed dose combinations; pediatric patients usually receive drops or syrup. Consult physician for appropriate dosing.
injectable
Adults: For severe infections, typically 1 g amoxicillin/200 mg clavulanic acid administered intravenously every 8 hours. In very severe infections, this may be increased to every 6 hours. Dosage should be adjusted for renal impairment.
Children: For children 3 months and older, 30 mg/kg (based on amoxicillin component) administered intravenously every 8 hours. For very severe infections, this may be increased to every 6 hours. Dosage should be adjusted for renal impairment.
Side Effects
- Diarrhea (up to 20%)
- Nausea (up to 10%)
- Vomiting (up to 5%)
- Skin rash (up to 3%)
- Vaginal yeast infection (up to 2%)
Serious Side Effects
- Severe allergic reactions (anaphylaxis, angioedema)
- Clostridioides difficile-associated diarrhea (CDAD)
- Liver dysfunction (hepatotoxicity, jaundice)
- Stevens-Johnson syndrome or toxic epidermal necrolysis
- Kidney problems (interstitial nephritis)
- Blood disorders (e.g., thrombocytopenia, leukopenia)
Contraindications
This medication is contraindicated in patients with a history of severe hypersensitivity reactions (e.g., anaphylaxis, Stevens-Johnson syndrome) to amoxicillin, clavulanic acid, or any other penicillin-class antibiotic. It is also contraindicated in patients with a history of amoxicillin/clavulanic acid-associated jaundice or hepatic dysfunction.
Drug Interactions
Significant interactions include: Warfarin (may increase INR, requiring monitoring); Methotrexate (may increase methotrexate levels and toxicity); Allopurinol (may increase the incidence of skin rash); Oral contraceptives (efficacy may be reduced, though evidence is limited, additional contraceptive methods may be advised). Always inform your doctor or pharmacist about all medications and supplements you are taking.
Pregnancy & Lactation
Category: B
Amoxicillin/clavulanic acid is classified as Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Consult your doctor.
Storage
Tablets and dry powder for oral suspension should be stored at room temperature, typically between 15°C and 30°C (59°F and 86°F), protected from moisture. Reconstituted oral suspension should be stored in a refrigerator (2°C to 8°C or 36°F to 46°F) and discarded after 7 to 10 days, depending on the specific product label. Injectable formulations should be stored as per manufacturer's instructions, typically below 25°C, and reconstituted solutions used promptly.
Clinical Tips
To minimize gastrointestinal upset, take this medication at the start of a meal. It is crucial to complete the full prescribed course of treatment, even if you start to feel better, to ensure the infection is fully eradicated and to prevent the development of antibiotic resistance. This antibiotic is not effective against viral infections like the common cold or flu. If you develop severe diarrhea, especially if it is watery or bloody, contact your doctor immediately.
Frequently Asked Questions
What is amoxicillin/clavulanic acid used for?
It is an antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, urinary tract, skin, and ears. It is not effective against viral infections like the common cold or flu.
How should I take amoxicillin/clavulanic acid?
It is typically taken by mouth, usually with food to minimize stomach upset. The exact dosage and frequency depend on the infection and your age, so always follow your doctor's instructions and complete the full course.
What are the common side effects of this medication?
Common side effects include diarrhea, nausea, vomiting, and skin rash. If these become severe or persistent, or if you experience any signs of an allergic reaction, consult your doctor or pharmacist immediately.
Can I stop taking amoxicillin/clavulanic acid once I feel better?
No, it is crucial to complete the entire prescribed course of antibiotics, even if your symptoms improve. Stopping early can lead to the infection returning and contribute to antibiotic resistance.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
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Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.