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Endocrine - Non-Steroidal Aromatase Inhibitors

Femapent 2.5 mg 30 f.c.tabs.

فيمابنت 2.5مجم 30 قرص

Letrozole

591.00 EGP

Unit price: 197.00 EGP

Specifications

Manufacturer
Penta pharma
Units / Box
3
Barcode
6224007738214
Price Updated
Jul 20, 2025

Uses & Indications

Letrozole is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. This includes adjuvant treatment of early breast cancer, extended adjuvant treatment of early breast cancer after 5 years of tamoxifen therapy, and first-line treatment of advanced breast cancer. It is also used for advanced breast cancer in women with natural or artificially induced postmenopausal status after relapse or disease progression following antiestrogen therapy. Off-label, letrozole is sometimes used for ovulation induction in women with infertility, particularly those with polycystic ovary syndrome (PCOS).

How It Works

Letrozole is a non-steroidal aromatase inhibitor. Aromatase is an enzyme that converts androgens (male hormones) into estrogens (female hormones) in peripheral tissues, such as fat, muscle, and breast tissue. By inhibiting aromatase, letrozole significantly reduces the amount of estrogen circulating in the body. In hormone receptor-positive breast cancer, estrogen can stimulate cancer cell growth. By lowering estrogen levels, letrozole helps to slow or stop the growth of these cancer cells.

Dosage & Administration

tablet

Adults: For breast cancer: The usual dose is 2.5 mg orally once daily. For ovulation induction (off-label): Typically 2.5 mg or 5 mg orally once daily for 5 days, starting on day 2, 3, 4, or 5 of the menstrual cycle, for a maximum of 6 cycles. Dosing should be determined and monitored by a healthcare professional.

Children: Letrozole is not recommended for use in children.

Side Effects

  • Hot flashes (up to 50%)
  • Joint pain (arthralgia, up to 20-30%)
  • Fatigue (up to 20%)
  • Sweating (up to 15%)
  • Nausea (up to 15%)
  • Headache (up to 10-20%)
  • Dizziness (up to 10%)
  • Bone pain (up to 10%)
  • Weight gain (up to 10%)

Serious Side Effects

  • Osteoporosis and fractures (due to significant estrogen deprivation, risk increases with long-term use)
  • Cardiovascular events (e.g., hypercholesterolemia, ischemic events, hypertension)
  • Thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism)
  • Severe skin reactions (rare, e.g., Stevens-Johnson syndrome)
  • Hepatotoxicity (rare, liver enzyme elevations)

Contraindications

Letrozole is contraindicated in patients with known hypersensitivity to letrozole or any of its excipients. It is also contraindicated in premenopausal women, during pregnancy, and during lactation. For ovulation induction, it should only be used under strict medical supervision in premenopausal women.

Drug Interactions

Concomitant use of letrozole with tamoxifen or estrogen-containing medications (e.g., hormone replacement therapy, oral contraceptives) should be avoided as these can reduce the effectiveness of letrozole. Letrozole is metabolized by CYP3A4 and CYP2A6; therefore, strong inhibitors or inducers of these enzymes may alter letrozole concentrations. Consult your doctor or pharmacist regarding all medications, including herbal supplements, before starting letrozole.

Pregnancy & Lactation

Category: X

Letrozole is contraindicated in pregnancy. It can cause fetal harm when administered to a pregnant woman. Premenopausal women should use effective contraception during treatment with letrozole and for at least 3 weeks after the last dose.

Storage

Store letrozole tablets at room temperature, between 20°C and 25°C (68°F and 77°F). Keep the tablets in their original packaging, protected from moisture. Do not store in the bathroom. Keep out of reach of children.

Clinical Tips

Take letrozole at approximately the same time each day, with or without food. It is important to continue treatment for the prescribed duration, even if you feel well. Due to the risk of bone loss, your doctor may recommend calcium and vitamin D supplementation and regular bone density monitoring. Report any new or worsening joint pain, hot flashes, or unusual bleeding to your healthcare provider.

Frequently Asked Questions

What is letrozole used for?

Letrozole is primarily used to treat hormone receptor-positive breast cancer in postmenopausal women. It is also used off-label for ovulation induction in some cases of infertility, particularly in women with PCOS, under strict medical supervision.

How should I take letrozole?

You should take letrozole orally once daily, at approximately the same time each day, with or without food. It is crucial to follow your doctor's instructions regarding the dosage and duration of treatment. Do not stop taking it without consulting your healthcare provider.

What are the common side effects of letrozole?

Common side effects include hot flashes, joint pain, fatigue, sweating, nausea, and headache. These are often manageable, but if they become severe or persistent, consult your doctor or pharmacist for advice.

Can letrozole be used to get pregnant?

Yes, letrozole is sometimes used off-label to induce ovulation in women experiencing infertility, especially those with polycystic ovary syndrome (PCOS). This use requires careful monitoring by a fertility specialist due to potential risks and the need for precise timing.

How long do I need to take letrozole for breast cancer?

The duration of letrozole treatment for breast cancer varies depending on the specific type and stage of cancer, and your individual treatment plan. It can range from several years (e.g., 5 years or more) as adjuvant or extended adjuvant therapy. Always follow your oncologist's recommendations.

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Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.