Ibuprofen 400mg 10 tab.
ايبوبروفين 400مجم 10 اقراص
Ibuprofen
Unit price: 17.00 EGP
Specifications
Uses & Indications
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, reduction of fever, and management of inflammation. It is indicated for conditions such as headaches, dental pain, menstrual pain (dysmenorrhea), muscle aches, back pain, minor arthritis pain, and symptoms associated with the common cold or flu.
How It Works
Ibuprofen exerts its therapeutic effects by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the synthesis of prostaglandins, which are lipid compounds that play a key role in mediating pain, inflammation, and fever responses in the body. By reducing prostaglandin production, ibuprofen helps to alleviate these symptoms.
Dosage & Administration
drops
Adults: Not typically used for adults. Consult a physician or pharmacist for appropriate adult formulations.
Children: Typically 5-10 mg/kg per dose, every 6-8 hours as needed. Do not exceed 4 doses in 24 hours. The maximum daily dose is 40 mg/kg or 400 mg, whichever is less. Consult a physician for exact dosing based on the child's weight and age.
syrup
Adults: 200-400 mg (e.g., 10-20 ml of 100mg/5ml syrup or 5-10 ml of 200mg/5ml syrup) every 4-6 hours as needed. Do not exceed 1200 mg/day for over-the-counter (OTC) use.
Children: Typically 5-10 mg/kg per dose, every 6-8 hours as needed. Do not exceed 4 doses in 24 hours. The maximum daily dose is 40 mg/kg or 400 mg, whichever is less. Consult a physician for exact dosing based on the child's weight and age.
sachet
Adults: For pain and fever, 200-400 mg every 4-6 hours as needed. Do not exceed 1200 mg/day for over-the-counter (OTC) use. Doses up to 2400 mg/day may be used under medical supervision for specific conditions.
Children: Not typically recommended for children under 12 years without medical advice. For children 12 years and older, 200-400 mg every 4-6 hours as needed, not exceeding 1200 mg/day.
tablet
Adults: For pain and fever, 200-400 mg every 4-6 hours as needed. Do not exceed 1200 mg/day for over-the-counter (OTC) use. Doses up to 2400 mg/day may be used under medical supervision for specific conditions.
Children: Not typically recommended for children under 12 years without medical advice. For children 12 years and older, 200-400 mg every 4-6 hours as needed, not exceeding 1200 mg/day.
topical
Adults: Apply a thin layer of gel or cream to the affected area 2-4 times daily. Wash hands thoroughly after application. Do not apply to broken or irritated skin.
Children: Consult a physician. Not generally recommended for children under 12 years without medical advice.
suppository
Adults: 500 mg to 1000 mg 2-3 times daily. The maximum daily dose is 2400 mg.
Children: Typically 5-10 mg/kg per dose, every 6-8 hours as needed. Do not exceed 4 doses in 24 hours. The maximum daily dose is 40 mg/kg or 400 mg, whichever is less. Consult a physician for exact dosing based on the child's weight and age.
effervescent
Adults: For pain and fever, 200-400 mg every 4-6 hours as needed. Do not exceed 1200 mg/day for over-the-counter (OTC) use. Doses up to 2400 mg/day may be used under medical supervision for specific conditions.
Children: Not typically recommended for children under 12 years without medical advice. For children 12 years and older, 200-400 mg every 4-6 hours as needed, not exceeding 1200 mg/day.
Side Effects
- Nausea (1-10%)
- Vomiting (1-10%)
- Dyspepsia (indigestion) (1-10%)
- Abdominal pain (1-10%)
- Diarrhea (1-10%)
- Constipation (1-10%)
- Headache (1-10%)
- Dizziness (1-10%)
Serious Side Effects
- Gastrointestinal bleeding or ulceration
- Acute kidney injury
- Increased risk of cardiovascular thrombotic events (e.g., heart attack, stroke), especially with prolonged high-dose use
- Severe allergic reactions (e.g., anaphylaxis, angioedema)
- Liver dysfunction
- Exacerbation of hypertension
- Fluid retention and edema
Contraindications
Ibuprofen is contraindicated in individuals with known hypersensitivity to ibuprofen, aspirin, or other NSAIDs. It should not be used in patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Other contraindications include active gastrointestinal bleeding or peptic ulcer disease, severe heart failure, severe renal impairment, severe hepatic impairment, and during the third trimester of pregnancy. It is also contraindicated for peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Drug Interactions
Ibuprofen can interact with several medications. Concomitant use with anticoagulants (e.g., warfarin) increases the risk of bleeding. Concurrent use with other NSAIDs or aspirin may increase the risk of gastrointestinal side effects and bleeding. Corticosteroids can also increase the risk of GI ulceration or bleeding. Ibuprofen may reduce the antihypertensive effects of diuretics, ACE inhibitors, and ARBs, and increase the risk of renal impairment when used together. It can also increase plasma levels of lithium and methotrexate, potentially leading to toxicity. Selective serotonin reuptake inhibitors (SSRIs) may increase the risk of GI bleeding when taken with ibuprofen. Alcohol consumption can increase the risk of gastrointestinal irritation and bleeding.
Pregnancy & Lactation
Category: C (first and second trimesters), D (third trimester)
During the first and second trimesters of pregnancy, ibuprofen should only be used if the potential benefit justifies the potential risk to the fetus, and under the guidance of a healthcare professional. It is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential for fetal renal dysfunction. Consult your doctor or pharmacist before use during pregnancy.
Storage
Store ibuprofen products at room temperature, typically between 15-30°C (59-86°F), away from moisture and direct light. Keep all medications out of the reach of children.
Clinical Tips
To minimize stomach upset, it is advisable to take ibuprofen with food or milk. Do not exceed the recommended dose or duration of use without consulting a doctor or pharmacist, as this can increase the risk of serious side effects. Adequate hydration is important, especially when using NSAIDs. Patients should be aware of potential signs of gastrointestinal bleeding, such as black, tarry stools or vomiting blood, and seek immediate medical attention if these occur.
Frequently Asked Questions
Can I take ibuprofen on an empty stomach?
It is generally recommended to take ibuprofen with food or milk to minimize stomach upset and reduce the risk of gastrointestinal irritation. If stomach upset occurs, taking it with food may help.
How long does it take for ibuprofen to start working?
Ibuprofen typically starts to relieve pain or reduce fever within 30 to 60 minutes after taking an oral dose. The full effect may be noticed within 1 to 2 hours.
Is ibuprofen safe to take every day for chronic pain?
Long-term daily use of ibuprofen, especially at high doses, can increase the risk of serious side effects such as gastrointestinal bleeding, kidney problems, and cardiovascular events. For chronic pain, consult your doctor or pharmacist to discuss appropriate and safer long-term pain management strategies.
Can I take ibuprofen with paracetamol (acetaminophen)?
Yes, ibuprofen and paracetamol can generally be taken together, as they work differently to relieve pain and fever. However, it is important not to exceed the maximum recommended doses for either medication. Always consult your doctor or pharmacist before combining medications.
What should I do if I miss a dose of ibuprofen?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
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Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.