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General Health - Vitamin B Complex Supplements

Poly-b-bion 3 amp. for i.m inj. 3ml

بولي-بي-بيون 3 امبولات عضل 3 مل

Vitamin b1+vitamin b6+vitamin b12

18.00 EGP

Unit price: 6.00 EGP

Specifications

Manufacturer
Alexandria
Units / Box
3
Price Updated
May 15, 2024

Uses & Indications

This combination of Vitamin B1 (Thiamine), Vitamin B6 (Pyridoxine), and Vitamin B12 (Cobalamin) is primarily used for the treatment of various neurological disorders and conditions associated with deficiencies of these vitamins. Specific indications include peripheral neuropathy, diabetic neuropathy, sciatica, lumbago, trigeminal neuralgia, optic neuritis, and post-herpetic neuralgia. It is also used to address general vitamin B deficiencies.

How It Works

Vitamin B1 (Thiamine) is crucial for carbohydrate metabolism, nerve impulse transmission, and maintaining the integrity of nerve cells. Vitamin B6 (Pyridoxine) acts as a coenzyme in numerous metabolic processes, including amino acid metabolism, neurotransmitter synthesis (e.g., serotonin, norepinephrine, dopamine), and the formation of myelin, the protective sheath around nerve fibers. Vitamin B12 (Cobalamin) is essential for DNA synthesis, red blood cell formation, and the maintenance of the myelin sheath, which is vital for proper nerve function. Together, these vitamins play synergistic roles in supporting nerve regeneration, reducing inflammation, and alleviating neuropathic pain.

Dosage & Administration

tablet

Adults: Typically 1 tablet (e.g., containing B1 100mg, B6 100mg, B12 1000mcg) once daily, or as prescribed by a physician. The dose and duration of treatment may vary based on the patient's condition and response.

Children: Not routinely recommended for children without specific medical indication. Dosing should be determined by a physician based on the child's age, weight, and the severity of the deficiency or condition. Consult a physician.

injectable

Adults: For severe cases or acute symptoms, typically 1 ampoule (e.g., containing B1 100mg, B6 100mg, B12 1000mcg) administered intramuscularly once daily. For less severe conditions or maintenance, 1 ampoule 2-3 times per week, or as directed by a physician. The duration of treatment depends on the clinical response and the underlying condition.

Children: Not routinely recommended for children without specific medical indication. Dosing should be determined by a physician based on the child's age, weight, and the severity of the deficiency or condition. Consult a physician.

Side Effects

  • Nausea (approximately 1-5%)
  • Stomach upset (approximately 1-5%)
  • Diarrhea (approximately 1-3%)
  • Headache (approximately 1-5%)
  • Allergic skin reactions such as rash or itching (less than 1%)
  • Pain or tenderness at the injection site (for injectable forms, approximately 5-10%)

Serious Side Effects

  • Severe allergic reactions (anaphylaxis, very rare)
  • Peripheral neuropathy (with very high doses of Vitamin B6, typically exceeding 200 mg/day for prolonged periods)
  • Cardiac arrhythmias (extremely rare, primarily associated with rapid intravenous administration of high-dose thiamine)
  • Leber's disease exacerbation (in patients with pre-existing Leber's hereditary optic neuropathy, due to Vitamin B12)

Contraindications

This medication is contraindicated in individuals with known hypersensitivity to thiamine, pyridoxine, cobalamin, or any other component of the formulation. It should not be used in patients with Leber's hereditary optic neuropathy due to the potential risk of exacerbation with Vitamin B12.

Drug Interactions

Several medications can interact with B vitamins. Vitamin B6 can reduce the effectiveness of levodopa (used for Parkinson's disease), although this interaction is less significant when levodopa is co-administered with carbidopa. Phenobarbital and phenytoin levels may be reduced by Vitamin B6. Alcohol and certain diuretics can increase the excretion of Vitamin B1. Metformin, proton pump inhibitors (PPIs), and H2-receptor antagonists can decrease the absorption of Vitamin B12. Chloramphenicol may antagonize the hematologic response to Vitamin B12. Always inform your doctor or pharmacist about all medications and supplements you are taking.

Pregnancy & Lactation

Category: C

While individual B vitamins are essential during pregnancy and generally considered safe at recommended daily allowances, combination products containing higher doses should be used with caution. The safety of high-dose combination B vitamins during pregnancy has not been definitively established. This medication should only be used if the potential benefit justifies the potential risk to the fetus, and only under the direct supervision of a physician. Consult your doctor before use if you are pregnant or planning to become pregnant.

Storage

Store the medication at room temperature, typically below 30°C (86°F), away from direct light and moisture. Do not freeze. Keep all medications out of the reach of children.

Clinical Tips

This combination of B vitamins is often prescribed for nerve-related pain and to correct deficiencies. It is important to take the medication exactly as prescribed by your doctor and to complete the full course of treatment, even if symptoms improve. For injectable forms, some temporary pain or discomfort at the injection site is common. Report any persistent or severe side effects, or if your symptoms do not improve, to your doctor or pharmacist.

Frequently Asked Questions

What is this combination vitamin used for?

This combination of B1, B6, and B12 vitamins is primarily used to treat nerve pain conditions such as peripheral neuropathy, diabetic neuropathy, sciatica, and lumbago. It also helps address deficiencies of these essential B vitamins, which are crucial for proper nerve function and overall health.

How long does it take for these vitamins to work?

The onset of action can vary depending on the individual and the condition being treated. Some patients may experience relief from symptoms within a few days to weeks, while others may require longer treatment courses for optimal benefits. Consistency in taking the medication as prescribed is important for achieving the desired therapeutic effect.

Can I take this if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, it is crucial to consult your doctor before taking this medication. While B vitamins are essential, high doses in combination products should only be used if clearly indicated and under medical supervision, as the safety of high-dose combinations during pregnancy is not fully established.

Are there any foods I should avoid while taking this?

Generally, there are no specific foods that must be avoided while taking this combination of B vitamins. However, excessive alcohol consumption can interfere with vitamin B1 absorption and metabolism. Maintaining a balanced diet is always beneficial for overall health and vitamin absorption.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Consult your doctor or pharmacist if you have concerns about missed doses.

Similar — Vitamin b1+vitamin b6+vitamin b12

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Medical Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.