Vixadep 150mg s.r. 60 f.c. tab

Specifications

Uses & Indications

Bupropion is an antidepressant medication primarily used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). It is also indicated as an aid to smoking cessation, marketed under a different brand name for this purpose.

How It Works

Bupropion functions as a norepinephrine-dopamine reuptake inhibitor (NDRI). It selectively inhibits the neuronal reuptake of norepinephrine and dopamine, leading to increased concentrations of these neurotransmitters in the synaptic cleft. This action is believed to contribute to its antidepressant and smoking cessation effects.

Dosage & Administration

Side Effects

• Dry mouth (10-25%)
• Nausea (10-15%)
• Insomnia (10-20%)
• Headache (20-25%)
• Dizziness (5-10%)
• Constipation (5-10%)
• Sweating (5-10%)
• Tremor (5-10%)

Contraindications

Bupropion is contraindicated in patients with a seizure disorder, a current or prior diagnosis of bulimia or anorexia nervosa, or in patients undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines). It should not be used concomitantly with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment. Hypersensitivity to bupropion or any component of the formulation is also a contraindication.

Drug Interactions

Concomitant use of bupropion with MAOIs can lead to a hypertensive crisis. It should be used with caution with other drugs that lower the seizure threshold (e.g., antipsychotics, antidepressants, theophylline, systemic corticosteroids, tramadol). Bupropion is a strong inhibitor of CYP2D6 and can increase the plasma concentrations of drugs metabolized by this enzyme (e.g., metoprolol, venlafaxine, tricyclic antidepressants, antiarrhythmics like propafenone and flecainide). Co-administration with levodopa or amantadine may increase the risk of central nervous system toxicity. Alcohol consumption should be avoided or minimized due to an increased risk of seizures.

Pregnancy & Lactation

Category: C

Bupropion is classified as Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in pregnant women. Bupropion should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor before using this medication if you are pregnant or planning to become pregnant.

Storage

Store bupropion tablets at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect from light and moisture. Keep the medication in its original container and out of reach of children.

Clinical Tips

To minimize the risk of insomnia, it is advisable to take bupropion doses in the morning. Extended-release tablets should be swallowed whole and not crushed, chewed, or cut, as this can lead to rapid release of the drug and increased risk of side effects, including seizures. Patients should be advised to avoid or limit alcohol consumption during treatment due to an increased risk of seizures. Regular monitoring of blood pressure is recommended, especially in patients with pre-existing hypertension.

Frequently Asked Questions

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