Virecta plus 4 tab
فايركتا بلس 4 قرص
Sildenafil+dapoxetine
Unit price: 35.00 EGP
Specifications
Uses & Indications
Sildenafil is primarily used to treat erectile dysfunction (ED) in men, a condition where a man cannot achieve or maintain a penile erection sufficient for satisfactory sexual performance. It is also indicated for the treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity and delay clinical worsening.
How It Works
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). In the context of erectile dysfunction, it enhances the effects of nitric oxide, which is released in response to sexual stimulation. Nitric oxide activates guanylate cyclase, leading to increased levels of cGMP, which causes smooth muscle relaxation in the corpus cavernosum and allows for increased blood flow, resulting in an erection. For pulmonary arterial hypertension, sildenafil causes vasodilation of the pulmonary vasculature, reducing pulmonary arterial pressure and improving lung function.
Dosage & Administration
syrup
Adults: Not typically used as syrup for adults for ED. For PAH, adult dosing with oral suspension is generally 20 mg (e.g., 4 mL of a 10 mg/2 mL suspension) three times daily, approximately 4-6 hours apart. Consult your physician or pharmacist for specific instructions.
Children: For pulmonary arterial hypertension (PAH) in children, the typical starting dose is 0.5 mg/kg orally three times daily, adjusted based on response and tolerability, up to a maximum of 2 mg/kg per dose, not exceeding 20 mg per dose, three times daily. Consult your physician for precise weight-based dosing.
tablet
Adults: For erectile dysfunction, the usual starting dose is 50 mg taken orally approximately 1 hour before sexual activity. The dose may be adjusted to 25 mg or 100 mg based on efficacy and tolerability. Do not take more than once daily. For pulmonary arterial hypertension, the dose is 20 mg orally three times daily, approximately 4-6 hours apart.
Children: Not recommended for erectile dysfunction. For pulmonary arterial hypertension, pediatric dosing is typically with the oral suspension; consult your physician for specific guidance if tablets are considered.
Side Effects
- Headache (16-28%)
- Flushing (10-19%)
- Dyspepsia (7-17%)
- Nasal congestion (4-10%)
- Visual disturbances (e.g., blurred vision, cyanopsia, 3-11%)
- Dizziness (2-3%)
Serious Side Effects
- Priapism (prolonged erection lasting more than 4 hours)
- Sudden decrease or loss of vision (non-arteritic anterior ischemic optic neuropathy - NAION)
- Sudden decrease or loss of hearing
- Severe hypotension (especially when used with nitrates)
- Cardiovascular events (e.g., myocardial infarction, stroke)
- Allergic reactions
Contraindications
Sildenafil is contraindicated in patients with hypersensitivity to sildenafil or any component of the formulation. It is strictly contraindicated in patients concurrently using any form of organic nitrates (e.g., nitroglycerin, isosorbide dinitrate) due to the risk of severe hypotension. Concomitant use with guanylate cyclase stimulators (e.g., riociguat) is also contraindicated.
Drug Interactions
Nitrates: Concomitant use with organic nitrates is absolutely contraindicated due to the risk of severe and potentially fatal hypotension. Alpha-blockers: Co-administration with alpha-blockers (e.g., doxazosin, tamsulosin) may lead to symptomatic hypotension. A lower starting dose of sildenafil (25 mg) should be considered, and patients should be stable on alpha-blocker therapy before initiating sildenafil. CYP3A4 Inhibitors: Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, erythromycin, cimetidine) can significantly increase sildenafil plasma levels, potentially increasing the risk of side effects. A reduced starting dose of sildenafil (e.g., 25 mg) may be necessary. CYP3A4 Inducers: CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin) may decrease sildenafil plasma levels, potentially reducing its efficacy. Alcohol: Excessive alcohol consumption may increase the risk of hypotension and dizziness.
Pregnancy & Lactation
Category: B
Sildenafil is classified as Pregnancy Category B for its use in pulmonary arterial hypertension. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks.
Storage
Store sildenafil tablets and syrup at controlled room temperature, typically between 20°C and 25°C (68°F and 77°F). Protect from moisture and light. Keep the syrup bottle tightly closed. Do not freeze. Keep out of reach of children.
Clinical Tips
For erectile dysfunction, sildenafil typically starts working within 30-60 minutes after ingestion. Its effect can be delayed if taken with a high-fat meal. Do not take more than one dose in a 24-hour period. If you experience an erection lasting longer than 4 hours, seek immediate medical attention to prevent permanent damage. This medication does not protect against sexually transmitted diseases.
Frequently Asked Questions
How long does sildenafil take to work for erectile dysfunction?
Sildenafil typically starts working within 30 to 60 minutes after ingestion for erectile dysfunction. Its effect may be delayed if taken with a high-fat meal.
Can I take sildenafil every day?
For erectile dysfunction, sildenafil should not be taken more than once daily. For pulmonary arterial hypertension, it is typically prescribed to be taken three times daily as directed by a physician.
What should I do if my erection lasts longer than 4 hours after taking sildenafil?
If you experience an erection that lasts longer than 4 hours, you should seek immediate medical attention. This condition, known as priapism, can cause permanent damage if not treated promptly.
Is sildenafil safe for women to use?
Sildenafil is approved for use in women for pulmonary arterial hypertension. However, it is not approved for female sexual dysfunction, and its safety and efficacy for this indication have not been established.
Does food affect how sildenafil works?
Taking sildenafil with a high-fat meal can delay the absorption of the medication, meaning it may take longer to start working. For optimal effect in erectile dysfunction, it is often recommended to take it on an empty stomach or with a light meal.
Similar — Sildenafil+dapoxetine
Medical Disclaimer
The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting or changing any medication.